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FBO DAILY ISSUE OF APRIL 30, 2003 FBO #0517
SOLICITATION NOTICE

A -- Record abstraction, data entry, and file development from the pilot study of the follow-up to the Stavanger Nested Case-Control Study of Pre-Clampsia

Notice Date

4/28/2003
 

Notice Type

Solicitation Notice
 

Contracting Office

Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Research Contracts Br., 6120 Executive Blvd. EPS Suite 600, Rockville, MD, 20852
 

ZIP Code

20852
 

Solicitation Number

NCI-30047-NG
 

Archive Date

5/29/2003
 

Point of Contact

Malinda Holdcraft, Purchasing Agent, Phone (301) 402-4509, Fax (301) 402-4513, - Renita Smith, Contract Specialist, Phone 301-496-8612, Fax 301-480-0241,
 

E-Mail Address

holdcram@exchange.nih.gov, rs442i@nih.gov
 

Description

The National Cancer Institute (NCI), Basic Research Laboratory (BRL), Center for Cancer Research (CCR) plans to procure record abstraction, data entry, and file development from the pilot study of the follow-up to the Stavanger Nested Case-Control Study of Preeclampsia with Norwegian University of Science and Technology, School of Medicine, NO-7489 Trondheim, Norway. The acquisition is being conducted under the simplified acquisition procedures authorized in FAR Part 13. The North American Industry Classification System Code is 541710 and the business size standard is 500 employees. Background: The Basic Research Laboratory, Center for Cancer Research, NCI, requires the data entry of and file development from the pilot study of questionnaires and other data collection techniques in a high-risk population of mothers and children who participated in a birth study when the mothers suffered from preeclampsia during the index pregnancy in comparison with an age-matched set of normotensive controls (mothers and their offspring). The ultimate purpose of this research project is to explore the biological mechanisms underlying why women who suffered from preeclampsia during pregnancy and their offspring are at significantly reduced risk of breast cancer (in mothers and daughters of that pregnancy) while the male offspring are at the lowest risk of prostate cancer identified in the literature. The information collected during the pretest and pilot study will need to be keyed, entered, and developed in an analytic file to enable the investigators at NCI in collaboration with The Rogaland Hospital, Stavanger, Norway to compare the maternal and child responses to the pilot study forms and the anthropometric and pubertal stage data in mothers and their offspring from the preeclamptic pregnancy with mothers and offspring from the normotensive pregnancy and thereby develop the final forms for a follow-up of the total cohort with the ultimate goal of identifying hormonal and other mechanisms associated with the lowered cancer risk in this population. Other information for the data file arise from anthropometric measurements of weight and of height taken when the children were one, two, three, and four years of age as part of the routine public health clinic visits. This information in combination with the pilot data shall then form a profile of the growth data on the children. Dr. Lars Vatten was the primary author to the research based in the Rogaland Hospital in Stavanger, Norway of the population-based study of women diagnosed with preeclampsia in pregnancy and their offspring and a comparable set of normotensive controls. His analysis of the original birth study identified significant growth retardation in newborns of preeclamptic in contrast with newborns of normotensive mothers as well as hormonal differences in the cord blood of the offspring of the two pregnancies. These hormones are associated with reduced risk of breast cancer in animal models and in human epidemiologic research. Public health nurses in Norway routinely measure weight and length in infancy and early childhood and record the data in a health record available for abstraction, after parental consent. It is important to the NCI that an evaluation of the early childhood anthropometric data be (abstracted, coded, and) entered in a file to determine whether the offspring of preeclamptic pregnancies experienced catch-up in weight and/or height since birth; these results will have implications for the timing of the follow-up of the full study population. It is also necessary to key, enter and analyze the data from the pretest and pilot forms and other tools for development of final forms for use in a follow-up of this population, when the offspring enter puberty and adolescence. This is the only population-based study to date of preeclampsia and these women represent all women, who were diagnosed with pre-eclampsia in pregnancy in the birth years from 1993 through 1995 who resided in the Stavanger area in Norway. The NCI has the opportunity to develop a follow-up of these mothers and children, linking with the original study database. The questionnaire items focus on dietary intake during the index pregnancy and since the birth of the index child, lifestyle and demographic characteristics, family history of cancer, and family history of reproductive disease, including preeclampsia in the mother's and biological father's families. The pretest and pilot of this form in the mothers and the pretest of a brief questionnaire about physical activity in children aged 10 years shall provide data to examine whether NCI can expect differences in the children of the two pregnancies and thereby provide the rationale for the conduct of the follow-up. Given the large sample size of 1,000 in the original birth study, there is the opportunity to have the statistical power to compute hormonal and other growth factor differences in the study population. Contractor Requirements: The Contractor shall perform the following tasks: 1) Obtain informed consent from a pilot study sample of mothers and offspring to abstract anthropometric data from the public health record, 2) Train a record abstractor to identify the appropriate anthropometric data from the public health record, 3) Key, (code when applicable), enter and develop a file of the abstracted anthropometric data from the public health records and pilot study data, including: a) Responses from the maternal questionnaire, b) Responses from the child's physical activity questionnaire, c) Weight and heights from the health record, d) Program and run descriptive statistics on the pilot and health record data and e) Perform analysis of the pilot study data comparing responses in mothers and offspring of the preeclamptic and normotensive pregnancies. Period of Performance: June 1, 2003 through September 30, 2003. The Norwegian University of Science and Technology, School of Medicine is the only known source to the NCI that can provide the aforementioned requirements. The Investigator has been involved in the original birth study and has worked for many years with the Medical Director of The Rogaland Central Hospital. Their insights from the original study as well as their scientific leadership in the area of preeclampsia provide extraordinary knowledge and experience in the Norwegian linked birth-cancer registry system, the public health record system, and in this particular study population. They have worked with the study data sets over the years and can thereby lead a team in the data analysis of the pilot study and early childhood anthropometric data. Therefore the background of the population, nature of its low risk for cancer, as well as the expertise and educational background of the Investigator and his team of data abstractors and analysts are all reasons for the sole source justification. This notice of intent is not a request for competitive quotation. However, if any interested party believes it can meet the above requirements, it may submit a statement of capabilities. The capability statement and any other furnished information must be in writing and must contain material in sufficient detail to allow NCI to determine if the party can fully meet the requirements herein. Capability statements must be received in the contracting office by 1:00 PM EDT (local Washington DC time) on May 14, 2003. If you have any questions, please submit them in writing via electronic mail to Malinda Holdcraft, Purchasing Agent on holdcram@exchange.nih.gov or by fax 301-402-4513. A determination by the Government not to compete this proposed requirement based on responses to this notice is solely within the discretion of the Government. Information received shall be considered solely for the purpose of determining whether to conduct a competitive procurement. No collect calls will be accepted.
 

Place of Performance

Address: NIH/NCI, 9000 Rockville Pike, Bethesda, MD

Zip Code: 20892

Country: USA
 

Record

SN00313319-W 20030430/030428213318 (fbodaily.com)
 

Source

FedBizOpps.gov Link to This Notice
(may not be valid after Archive Date)

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