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SAMDAILY.US - ISSUE OF OCTOBER 19, 2025 SAM #8728
SOLICITATION NOTICE

A -- Smart Red Blood Cells (Smart-RBC)

Notice Date
10/17/2025 12:07:28 PM
 
Notice Type
Solicitation
 
NAICS
541714 — Research and Development in Biotechnology (except Nanobiotechnology)
 
Contracting Office
DEF ADVANCED RESEARCH PROJECTS AGCY ARLINGTON VA 222032114 USA
 
ZIP Code
222032114
 
Solicitation Number
DARPA-PS-26-02
 
Response Due
1/14/2026 11:59:00 PM
 
Archive Date
02/13/2026
 
Point of Contact
Dr. Christopher Bettinger, DARPA/BTO
 
E-Mail Address
Smart-RBC@darpa.mil
(Smart-RBC@darpa.mil)
 
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals in support of the Smart Red Blood Cells program (Smart-RBC). The DARPA Smart-RBC program aims to engineer red blood cells to contain novel biological features that can safely, temporarily, and reliably alter human physiology. Specifically, the Smart-RBC program will revolutionize blood products by creating �smart red blood cells� (SRBCs). SRBCs will be engineered to contain additional biological circuits consisting of three layers: Sense extracellular biomarkers; Decide next steps; Act by creating effector molecules that can alter metabolism or physiology. The program will identify the art-of-the-possible to create SRBCs to enhance human performance and maximize survival via hemostasis products. This program does not include clinical trials or direct human testing.
 
Web Link
SAM.gov Permalink
(https://sam.gov/workspace/contract/opp/a0160217c997497c897c3320db9dcb7f/view)
 
Record
SN07621640-F 20251019/251017230032 (samdaily.us)
 
Source
SAM.gov Link to This Notice
(may not be valid after Archive Date)

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